Simulations Plus

Simulations Plus

Drug Discovery & Development

About Simulations Plus

Simulations Plus is a leading provider of modeling and simulation software and consulting services for pharmaceutical and biotechnology companies. For over 30 years, the company has partnered with scientists and teams across the drug development lifecycle, supporting ADMET prediction, physiologically-based pharmacokinetic (PBPK) modeling, pharmacometrics, and quantitative systems pharmacology/toxicology (QSP/QST). The company's flagship products include GastroPlus for PBPK modeling, MonolixSuite for pharmacometrics, ADMET Predictor for machine learning-based ADMET modeling, DILIsym for quantitative systems toxicology, and Thales for QSP modeling. Simulations Plus serves 19 out of the top 20 pharmaceutical companies globally, with over 280 clients worldwide. The company combines mechanistic models with AI-enabled workflows in an integrated environment, helping clients move from discovery to regulatory submission with confidence. In addition to software, Simulations Plus offers expert consulting services across discovery, development, clinical operations, and commercialization phases. The company collaborates extensively with academic institutions, CROs, regulatory agencies including the FDA, EPA, and NIH, and maintains strong distributor networks in Brazil, China, India, Japan, and South Korea. Simulations Plus has entered into an agreement to be acquired by Altaris, a healthcare-focused investment firm, and will be combined with Chemical Computing Group.

Mission & Story

Mission

We Improve Quality of Life Through Innovative Solutions

Clinical Focus

Medical conditions and clinical areas addressed by Simulations Plus.

Drug-induced liver injury (DILI)Nonalcoholic fatty liver diseaseDrug-induced kidney injuryVarious therapeutic areas across drug development

Who It Serves

Pharmaceutical companiesBiotechnology companiesContract Research Organizations (CROs)Contract Development and Manufacturing Organizations (CDMOs)Academic institutionsRegulatory agenciesGovernment research organizations

Milestones & Awards

Recent Milestones

Entered into acquisition agreement with Altaris LLC to be combined with Chemical Computing Group; Multiple FDA grants awarded; NIH SBIR Phase II $1.5M grant for RENAsym kidney injury model development; Expanded research agreement with NIEHS

Key Partnerships

University of Buffalo UB Center of Excellence in Pharmacokinetics and PharmacodynamicsUniversity of MarylandUniversity of Florida College of PharmacyCatalentCyprotexEvotecLabCorpLonzaPAREXELPharmaronThermo FisherWuXi ApptecU.S. EPA/NIEHS/NTPU.S. FDANational Institutes of HealthBotanical Safety ConsortiumCosmetics EuropeChemical Computing Group (pending acquisition integration)

Company Details

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Last updated Jul 1, 2026

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