Human sex-specific hormone effects on cerebrovascular health in males and females.

Brittany Intzandt¹, Zacharie Potvin-Jutras², Claudine J Gauthier²

¹School of Kinesiology and Health Science | Centre for Integrative and Applied Neuroscience, Faculty of Health, York University, Toronto M3J 1P3, Canada; Rotman Research Institute, Baycrest Academy for Research and Education, Toronto M6A 2E1, Canada. Electronic address: bnintzan@yorku.ca.

²Department of Physics/School of Public Health, Concordia University, Montreal H4B 1R6, Canada; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada.

PubMed DOI

Abstract

Circulating sex hormone levels decrease in aging, influencing cerebrovascular health. Estradiol has been shown to support female vascular and brain health, though its effects across the menopausal transition remain unknown. Similarly, the influence of testosterone and other hormones in females is not clear. In males, testosterone is associated with positive health outcomes, but the effects of estr…

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