Peer-Reviewed Publication
Auton Neurosci2026;267103463.October 1, 2026Journal Article
Anatomical modeling of visceral afferent innervation in the rodent stomach.
Duyen Nguyen1, Mabelle Y Lin2, Jichao Ma3, Andrew M Kwiat3, Jin Chen3, Maci Heal4, Peter J Hunter2, Susan Tappan5, De-Pei Li6, Zixi Jack Cheng7
1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA. Electronic address: Duyen.Nguyen1103@ucf.edu.
2Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
3Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
4MBF Bioscience, Williston, VT, 05495, USA.
5Rock Maple Science, Hinesburg, VT, 05461, USA.
6Department of Medicine, Center for Precision Medicine, School of Medicine, University of Missouri, Columbia, MO, 65212, USA.
7Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA. Electronic address: Zixi.Cheng@ucf.edu.
Abstract
Understanding the sensory nervous system's precise innervation of visceral organs remains a major challenge in systems neuroscience, particularly for designing neuromodulatory therapies. Here, we introduce a digital twin of the rodent stomach that combines high-resolution structural images and nerve-specific mapping onto a common coordinate scaffold. Using a pipeline developed within the NIH SPARC…
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