Peer-Reviewed Publication
Drug Alcohol Depend2026;287113279.October 1, 2026Journal Article

Multilevel drivers and constraints of shifts from injecting to smoking opioids and stimulants: A qualitative study from the San Diego-Tijuana border region.

William H Eger1, Maia H Hauschild2, Erika L Crable3, Logan A Hehner4, Katie Bailey5, M Gudelia Rangel6, Alicia Harvey-Vera7, Carlos Vera8, Annick Bórquez9, Heather A Pines10, Eileen V Pitpitan11, Thomas L Patterson12, Steffanie A Strathdee13, Angela R Bazzi14
1School of Social Work, San Diego State University, San Diego, CA, USA; School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: weger0735@sdsu.edu.
2Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: mhh82@med.miami.edu.
3Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA; Center for Health Policy Research, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: elcrable@ucla.edu.
4Department of Psychology, Hartwick College, Oneonta, NY, USA. Electronic address: hehnerl@hartwick.edu.
5Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. Electronic address: kkbailey@health.ucsd.edu.
6Department of Population Studies, Colegio de la Frontera Norte, Tijuana, Mexico. Electronic address: grangel2009@gmail.com.
7School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: alvera@health.ucsd.edu.
8School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: cfvera@health.ucsd.edu.
9School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: aborquez@health.ucsd.edu.
10Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA; School of Public Health, San Diego State University, San Diego, CA, USA. Electronic address: hpines@sdsu.edu.
11School of Social Work, San Diego State University, San Diego, CA, USA. Electronic address: epitpitan@sdsu.edu.
12School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: tpatterson@health.ucsd.edu.
13School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: sstrathdee@health.ucsd.edu.
14Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA; Boston University School of Public Health, Boston, MA, USA. Electronic address: abazzi@health.ucsd.edu.

Abstract

BACKGROUND: Amidst declines in injecting opioids and stimulants across North America, we sought to explore multilevel drivers and constraints of shifts from injecting to smoking these substances among people with a history of injection drug use. METHODS: From October-December 2024, we conducted semi-structured qualitative interviews with individuals with histories of injection drug use in San Die…

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