Antifungal action of menthol and menthone against Botrytis cinerea: Physiological responses associated with membrane integrity, mitochondrial activity, and oxidative stress, and lipid nanoparticle formulation for its application.

Génesis Blanco¹, Washington Aniñir¹, Ignacio Jofré², Olga Rubilar³, Gonzalo Tortella¹, Andrés Quiroz⁴, Adalberto Benavides-Mendoza⁵, Paola Fincheira⁶

¹Center of Excellence in Biotechnology Research Applied to the Environment (CIBAMA-UFRO), Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Box 54-D, Temuco 4811230, Chile.

²Scientific and Technological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Av. Francisco Salazar 01145, Casilla 54-D, Temuco 4811230, Chile.

³Center of Excellence in Biotechnology Research Applied to the Environment (CIBAMA-UFRO), Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Box 54-D, Temuco 4811230, Chile; Department of Chemical Engineering, Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Casilla 54-D, Temuco 4811230, Chile.

⁴Center of Excellence in Biotechnology Research Applied to the Environment (CIBAMA-UFRO), Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Box 54-D, Temuco 4811230, Chile; Department of Chemical Sciences and Natural Resources, Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Casilla 54-D, Temuco 4811230, Chile.

⁵Department of Horticulture, Universidad Autónoma Agraria Antonio Narro, Saltillo 25315, Mexico.

⁶Center of Excellence in Biotechnology Research Applied to the Environment (CIBAMA-UFRO), Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Box 54-D, Temuco 4811230, Chile; Department of Chemical Engineering, Faculty of Engineering and Sciences, Universidad de La Frontera, Av. Francisco Salazar 01145, Casilla 54-D, Temuco 4811230, Chile. Electronic address: p.fincheira01@ufromail.cl.

PubMed DOI

Abstract

Botrytis cinerea causes gray mold and is considered the second most important fungal phytopathogen. Natural compounds such as menthol and menthone have emerged as sustainable tools for reducing fungal infections and mitigating the adverse effects of synthetic fungicides. Nevertheless, there is limited information about the physiological mechanisms of menthol and menthone on B. cinerea. This study…

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Mentioned Companies

Frontera
affiliation

MeSH Terms

Botrytis*Oxidative Stress*Nanoparticles*Mitochondria*Cell Membrane0Menthol*Antifungal Agents*Mycelium0Spores, Fungal0Lipids0Fungicides, Industrial0Hydrogen Peroxide0Microbial Sensitivity Tests0Hydrogen-Ion Concentration0Liposomes0

Keywords

Botrytis cinereaCell membrane damageMitochondrial activityOxidative stressSolid lipid nanoparticles

Article Info

PMID: 42594543
DOI: 10.1016/j.micres.2026.128665
Received: May 26, 2026
Accepted: August 5, 2026

How to Cite

Blanco G et al. Antifungal action of menthol and menthone against Botrytis cinerea: Physiological responses associated with membrane integrity, mitochondrial activity, and oxidative stress, and lipid nanoparticle formulation for its application. Microbiol Res2026;313128665. doi:10.1016/j.micres.2026.128665

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