Peer-Reviewed Publication
Diabetes Obes Metab2026September 1, 2026Journal Article

Quality Plus Quantity: Evaluation of a Virtual GLP-1 Programme With Physical Activity Support to Promote Healthy Body Composition Change During GLP-1 Weight Loss.

Lisa A Stanton1, Jeanean B Naqvi1, Susan M Devaraj1, Amanda McGuill1, Todd A Norwood1, Sarah Linke1
1Omada Health Inc., San Francisco, California, USA.

Abstract

AIMS: Glucagon-like peptide-1 (GLP-1) receptor agonists can produce rapid weight loss, but this loss is frequently accompanied by disproportionate loss of lean mass, particularly during the early phase of GLP-1-treatment. Physical activity (PA), particularly resistance training, is the most effective behavioural strategy for enhancing fat reduction while preserving lean mass. Our primary aim was t…

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