Health AI Central
Peer-Reviewed Publication
Crit Care Clin2026;42(4):777-793.October 1, 2026Journal Article

The Nonimmune Aspects of Sepsis.

Nicole P Juffermans1, Lies Langouche2, Nathan D Nielsen3
1Department of Intensive Care, The Emergency, Perioperative and Intensive Care Laboratory (EPIC Lab), Erasmus Medial Center, Rotterdam, the Netherlands. Electronic address: n.juffermans@erasmusmc.nl.
2Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
3Division of Pulmonary, Critical Care and Sleep Medicine, Section of Transfusion Medicine and Therapeutic Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
PubMed DOI

Abstract

This article highlights the most important nonimmune pathways in sepsis, with a focus on adaptive versus maladaptive mechanisms. Understanding of maladaptive mechanisms has high potential to enhance clinical care of sepsis in the near future.

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.