Peer-Reviewed Publication
Clin Transl Radiat Oncol2026;61101265.November 1, 2026Journal Article
Early and late CTCAE and patient-reported outcomes following lung cancer radiotherapy: A sex-stratified descriptive analysis from the REQUITE cohort.
Miguel E Aguado-Barrera1,2, Patricia Calvo-Crespo1,3, Begoña Taboada-Valladares1,3, Antonio Gomez-Caamaño1,3, Angel Carracedo2,4,5,6, David Azria7, Erik Briers8, Jenny Chang-Claude9,10, Dirk de Ruysscher11, Gilles Defraene12, Rebecca M Elliott13, Corinne Faivre-Finn14,15, Marzia Franceschini16, Olivia Fuentes-Rios1,2, Alexandra Giraldo17, Tommaso Giandini18, Sara Gutiérrez-Enríquez19, Philipp Heumann9, Daniel S Higginson20, Kerstie Johnson21, Maarten Lambrecht22, Yolande Lievens23, Meritxell Mollà17, Tiziana Rancati24, Tim Rattay21, Mónica Ramos17, Barry S Rosenstein25, Petra Seibold9, Elena Sperk26, Hilary Stobart27, Paul Symonds21, Christopher J Talbot28, Katrien Vandecasteele23, Liv Veldeman23, Tim Ward29, Adam Webb28, Catharine M L West13, , Vega Ana1,2,5
1Grupo Genética en Cáncer y Enfermedades Raras, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.
2Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain.
3Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Spain.
4Genomic Medicine Group, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
5Biomedical Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
6Genetics Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.
7Fédération Universitaire d'oncologie radiothérapie d'Occitanie Méditerranée, ICM, INSERM U1194 IRCM, Univ Montpellier, Montpellier, France.
8Patient Advocat, Hasselt, Belgium.
9Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
10Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
11Maastricht University Medical Center, Department of Radiation Oncology (Maastro clinic), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
12Department of Oncology, KU Leuven, Leuven, Belgium.
13Translational Radiobiology Group, Division of Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
14Clinical Oncology Department, The Christie NHS Foundation Trust, Manchester, United Kingdom.
15Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom.
16Radiation Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
17Department of Radiation Oncology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
18Medical Physics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
19Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
20Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
21Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
22Department of Radiation Oncology, UZ Gasthuisberg Leuven, Leuven, Belgium.
23Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, Belgium.
24Unit of Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
25Department of Radiation Oncology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
26Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
27Independent Cancer Patients' Voice, United Kingdom.
28Division of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
29Trustee Pelvic Radiation Disease Association, NCRI CTRad Consumer, United Kingdom.
Abstract
BACKGROUND: Long-term prospective data on lung cancer patients treated with radiotherapy are limited, restricting understanding of outcomes and sex-specific characteristics. The multicentre REQUITE study provides standardized follow-up data from an international cohort.
METHODS: We analysed longitudinal data from 530 lung cancer patients treated with radical radiotherapy (sequential or concurrent…
Create a free account to keep reading
Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.
Want unlimited research access? See Pro plans