Health AI Central
Peer-Reviewed Publication
Int J Surg Case Rep2026;138(9):3536-3542.September 1, 2026Case Reports

Sinonasal osteosarcoma of the ethmoid bone with decade-later recurrence presenting as early orbital apex syndrome: an 18-year case report.

Muhammad Ehtesham1, Hamza Khan Khattak1, Maryam Shoaib1, Imran Khan2, Azam Nawaz1, Kamil Ahmad Kamil3
1Department of Medicine, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
2Department of ENT, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
3Internal Medicine Department, Nasrat Bashir Curative Hospital, Kandahar, Afghanistan.
PubMed PMC DOI PDF

Abstract

INTRODUCTION: Primary ethmoid osteosarcoma is an exceptionally rare craniofacial malignancy, characterized by aggressive local invasion of adjacent structures. While most recurrences occur within the first 2-3 years, late relapse after long-term disease-free survival is exceedingly uncommon. CASE PRESENTATION: We describe an 18-year clinical course of a patient first diagnosed with ethmoidal chon…

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