STK11 Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical Adenocarcinoma.

Emma W Robinson^1,2, Elisabeth A Murphy³, Anaseidy Albanez⁴, Sonam Tulsyan¹, Hong Lou², Yi Xie¹, Weiyin Zhou², Qian Yang¹, Tawnjerae Joe^1,5, Tongwu Zhang¹, Jia Liu², Wen Luo², Dongjing Wu², Herbert Higson², Mathias Viard^6,7, Mary Carrington^6,7,8, Matthew Oberley³, Hesler Morales^4,9, Lisa Mirabello¹, Enrique Alvirez^10,11, Roberto Orozco⁹, Eduardo Gharzouzi¹², Michael Dean¹

¹Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.

²Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Rockville, Maryland, USA.

³Caris Life Sciences, Irving, Texas, USA.

⁴Instituto de Cancerología (INCAN), Guatemala City, Guatemala.

⁵Interdisciplinary Health Program, Northern Arizona University, Flagstaff, Arizona, USA.

⁶Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.

⁷Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

⁸Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.

⁹Hospital General San Juan de Dios, Guatemala City, Guatemala.

¹⁰Hospital Central Universitario "Dr. Antonio M Pineda", Barquisimeto, Lara State, Venezuela.

¹¹Universidad Andino de Cusco, Cusco, Peru.

¹²Integra Cancer Center, Guatemala City, Guatemala.

PubMed DOI

Abstract

Cervical adenocarcinoma accounts for 15%-20% of cervical cancers and is associated with poorer survival and reduced response to screening and immunotherapy compared with squamous cell carcinoma (SCC). The genomic drivers underlying this molecular subgroup remain incompletely characterized. Whole-exome sequencing was performed on 302 invasive cervical cancers from Guatemala and Venezuela. Structura…

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