Health AI Central
Peer-Reviewed Publication
Mod Pathol2026;101079.September 7, 2026Journal Article

An Agreement Study of Stromal Cellularity, Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast.

Xiaoxian Li1, Yulin Haw2, Yi Liu3, Jabed Iqbal4, Syed Salahuddin Ahmed4, Hua Guo5, Shi Wei5, Sayeeda Yasmeen6, Julia Ye7, Yanjun Hou8, Reza Eshraghi9, Huina Zhang10, Di Ai11, Gloria Zhang12, Anupma Nayak13, Sahar Jalali Farahani14, Marilin Rosa15, Haiying Zhan16, Paul Buttars17, Rania Bakkar18, Stuart Schnitt19, Edi Brogi14, Kimberly Allison20, Laura C Collins21, Aysegul Sahin11, Kalliopi P Siziopikou22, Yunn-Yi Chen7, Thaer Khoury6
1Department of Pathology and Laboratory Medicine, East Carolina University, Greenville, North Carolina; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia. Electronic address: lix25@ecu.edu.
2Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.
3Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia.
4Department of Anatomic Pathology, Singapore General Hospital, Singapore.
5Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
6Department of Pathology, Roswell Park Cancer Center, Buffalo, New York.
7Department of Pathology, University of California San Francisco, San Francisco, California.
8Department of Pathology, Wake Forest University, Winston-Salem, North Carolina.
9Department of Pathology, Moffitt Cancer Center, Tampa, Florida.
10Department of Pathology, University of Rochester, Rochester, New York.
11Department of Pathology, MD Anderson Cancer Center, Houston, Texas.
12Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.
13Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
14Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
15Department of Pathology, NeoGenomics Laboratories, Fort Myers, Florida.
16Department of Pathology, Yale University, New Haven, Connecticut.
17Department of Pathology and Immunology, Washington University, St. Louis, Missouri.
18Department of Pathology, City of Hope National Cancer Center, Duarte, California.
19Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
20Department of Pathology, Stanford University, Stanford, California.
21Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
22Department of Pathology, University of Arizona, Tucson, Arizona.
PubMed DOI

Abstract

Accurate evaluations of stromal cellularity, stromal cell atypia, and tumor border are critical for the classification of fibroepithelial lesions. This study evaluated the agreement among 19 subspecialized academic breast pathologists for evaluation of these morphologic features. Nineteen pathologists evaluated 54 images for both stromal cellularity and stromal cell atypia and 23 images for tumor…

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