Health AI Central
Peer-Reviewed Publication
Nat Biotechnol2026September 7, 2026Journal Article

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

Alex Zhavoronkov1,2,3, Fedor Galkin4, Shan Chen5, Feng Ren5, Alex Aliper4, Mikhail Durymanov4, Denis Sidorenko4, Hui Cui5, Jing-Dong J Han6,7, Hao Xu6, Xiaodong Liu8,9,10, Zuojun Xu11, Christoph Kuppe12, M Austin Argentieri13,14, Kejun Ying15,16,17, Ludger J E Goeminne18,19, Mahdi Moqri18,19, Alexander Tyshkovskiy18,19, Vadim N Gladyshev18,19
1Insilico Medicine AI Limited, Abu Dhabi, United Arab Emirates. alex@insilico.com.
2Insilico Medicine Shanghai Ltd., Shanghai, China. alex@insilico.com.
3Insilico Medicine US Inc., Cambridge, MA, USA. alex@insilico.com.
4Insilico Medicine AI Limited, Abu Dhabi, United Arab Emirates.
5Insilico Medicine Shanghai Ltd., Shanghai, China.
6Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China.
7Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China.
8Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
9School of Life Sciences, Westlake University, Hangzhou, China.
10Research Center for Industries of the Future, Westlake University, Hangzhou, China.
11Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
12Nephrology Department, RWTH Aachen University, Aachen, Germany.
13Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
14Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
15The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
16Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
17Institute for Protein Design, University of Washington, Seattle, WA, USA.
18Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
19Broad Institute of MIT and Harvard, Cambridge, MA, USA.
PubMed DOI

Abstract

Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tracking the immediate effectors of biological change, may excel in providing aging biomarkers or mechanistic insight. Here we compa…

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