Health AI Central
Peer-Reviewed Publication
J Pathol2026September 8, 2026Journal Article

CAFs-mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression.

Huachi Li1, Jun Hu2, Lei Huang3, Zihao Wang1, Haoran Tao1, Feng Cao4, Min Xie1
1Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji MedicaI College, Huazhong University of Science and Technology, Hubei Provincial Clinical Research Center for Colorectal Cancer; Wuhan Clinical Research Center for Colorectal Cancer, Wuhan, PR China.
2Department of Spine Surgery, the Fourth Hospital of Wuhan, Wuhan, PR China.
3Department of Urological Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
4Department of Hepatobiliary, Gastrointestinal Surgery, Shenzhen Guangming District People's Hospital, Shenzhen, PR China.
PubMed DOI

Abstract

The progression of colorectal cancer (CRC) is critically regulated by cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through metabolic reprogramming. Findings indicate that lactate se…

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