Peer-Reviewed Publication
Thromb Res2026;265109829.September 9, 2026Journal Article

ReSTORE-PE (Rehabilitation to Support Total Recovery after Pulmonary Embolism): Development of a co-designed rehabilitation programme for post-pulmonary embolism syndrome.

Caoimhe Kenny1, Fiona Curran2, Frederikus A Klok3, Olive Lennon4, James Matthews5, Fionnuala Ni Ainle6, Rachel P Rosovsky7, Grainne O'Donoghue8
1School of Public Health, Physiotherapy & Sports Science, University College Dublin, Health Sciences Building, D04 V1W8, Ireland. Electronic address: caoimhe.kenny2@ucdconnect.ie.
2School of Public Health, Physiotherapy & Sports Science, University College Dublin, Health Sciences Building, D04 V1W8, Ireland. Electronic address: fiona.curran@ucd.ie.
3Department of Medicine - Thrombosis and Haemostasis, LUMC, Albinusdreef 2, Leiden, 2333 ZA, Netherlands. Electronic address: f.a.klok@lumc.nl.
4School of Public Health, Physiotherapy & Sports Science, University College Dublin, Health Sciences Building, D04 V1W8, Ireland. Electronic address: olive.lennon@ucd.ie.
5School of Public Health, Physiotherapy & Sports Science, University College Dublin, Health Sciences Building, D04 V1W8, Ireland. Electronic address: james.matthews@ucd.ie.
6University College Dublin, School of Medicine, Dublin 4, D04 V1W8, Ireland. Electronic address: fniainle@mater.ie.
7Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States of America. Electronic address: rprosovsky@mgh.harvard.edu.
8School of Public Health, Physiotherapy & Sports Science, University College Dublin, Health Sciences Building, D04 V1W8, Ireland. Electronic address: grainne.odonoghue@ucd.ie.

Abstract

INTRODUCTION: Approximately 50% of pulmonary embolism (PE) survivors experience persistent physical and psychological symptoms consistent with post-pulmonary embolism syndrome (PPES), negatively affecting quality of life, functional recovery, and engagement in healthy lifestyle behaviours. Although rehabilitation is recommended following PE, limited evidence exists to guide intervention design for…

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