Peer-Reviewed Publication
JHEP Rep2026;102031.September 11, 2026Journal Article
Prevalence and Significance of Combined Low Muscle Volume and High Muscle Fat in Patients with Child-Pugh A-B Cirrhosis.
Mikael Fredrik Forsgren1, Daniel Sjögren2, Henrik Stjernman3, Patrik Nasr4, Wile Balkhed5, Anna Cederborg6, Markus Holmberg7, Wolf Bartholomä8, Cecilia Jönsson7, Peter Lundberg9, Martin Rejler10, Nils Dahlström8, Stergios Kechagias11, Olof Dahlqvist Leinhard12, Mattias Ekstedt13
1Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; AMRA Medical AB, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden. Electronic address: mikael.f.forsgren@liu.se.
2Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Medicine, Höglandssjukhuset Eksjö, Region Jönköping County Council, Eksjö, Sweden.
3Department of Internal Medicine, Ryhov Hospital Jönköping, Region Jönköping County Council, Jönköping, Sweden.
4Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linköping, Region Östergötland, Linköping, Sweden; Wallenberg Center for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden.
5Clinical Department of Gastroenterology and Hepatology in Linköping, Region Östergötland, Linköping, Sweden.
6Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
7Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
8Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Clinical Department of Radiology in Linköping, Region Östergötland, Linköping, Sweden.
9Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Clinical Department of Radiology in Linköping, Region Östergötland, Linköping, Sweden; Clinical Department of Medical Radiation Physics, Region Östergötland, Linköping, Sweden.
10Futurum, Academy for Healthcare, Region Jönköping County, Jönköping, Sweden; The Jönköping Academy for Improvement of Health and Welfare, Hälsohögskolan, Jönköping University, Jönköping, Sweden.
11Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linköping, Region Östergötland, Linköping, Sweden.
12Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; AMRA Medical AB, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
13Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linköping, Region Östergötland, Linköping, Sweden.
Abstract
BACKGROUND & AIMS: Physical frailty and sarcopenia are linked to adverse outcomes and higher healthcare utilisation in liver cirrhosis. A magnetic resonance imaging (MRI) assessment combining thigh muscle volume and muscle fat infiltration identifies muscle composition (MC) phenotypes, where adverse MC (high fat, low volume) independently predicts all-cause mortality. We aimed to determine MC prev…
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