Prenatal stress enhances vulnerability to apomorphine reward and affects 5HT-1A receptor sensitivity in adult rats.

Huma Ikram¹, Rumaisa Zakir², Hannah Tariq², Darakhshan J Haleem³

¹Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan. Electronic address: huma_biochemist@yahoo.com.

²Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.

³Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan; Neuro science Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, 75270, Pakistan.

PubMed DOI

Abstract

Prenatal stress has recently become known as one of the major factors influencing neurodevelopmental changes resulting in higher susceptibility to drug abuse in adults. The current investigation is aimed at evaluation of the effect of prenatal unpredictable chronic mild stress on susceptibility to apomorphine reward and functioning of 5HT-1A receptors in adulthood in male rats. The female rats wer…

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