Genomic Characterisation of Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter hormaechei Clinical Isolates from Nigeria: Evidence of Resistance, Virulence, and Putative Plasmid-Mediated Gene Sharing.

Sunday Babatunde Akinde^1,2,3, Ademola Ayodele Adesoye^4,5, Olabisi Olaniyi Ojo⁶, Odunola Oluwaseun Oluwajide⁷, Abideen Akinkunmi Wahab⁴, Oluwaseyi Paul Olaniyan^5,8, Emmanuel Sunday Fajoyegbe^4,5, Inimary Toby-Ogundeji⁹, Nusrah Bolatito Afolabi-Balogun¹⁰, Omokaro Obire¹¹, Elijah Kolawole Oladipo^12,13, Fatimah Adenike Ajadi¹⁴, Waidi Folorunso Sule^4,5, Olasunbo Aina Olasupo^4,5, Omotayo Opemipo Oyedara¹⁵, Janet Olubukola Olaitan⁴

¹Department of Microbiology, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

²Microbial Biotechnology and One Health Research Laboratory, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

³Multidisciplinary Research Laboratory, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

⁴Department of Microbiology, Osun State University, Osogbo, Nigeria.

⁵Microbial Biotechnology and One Health Research Laboratory, Osun State University, Osogbo, Nigeria.

⁶Department of Natural Sciences, Albany State University, Albany, GA, USA.

⁷Department of Science Laboratory Technology, Osun State University, Osogbo, Nigeria.

⁸Multidisciplinary Research Laboratory, Osun State University, Osogbo, Nigeria.

⁹Biology Department, University of Dallas, Irving, TX, USA.

¹⁰Molecular Biology and Genetic Diversity Laboratory, Biochemistry Unit, Fountain University, Osogbo, Nigeria.

¹¹Department of Microbiology, Rivers State University, Port Harcourt, Nigeria.

¹²Molecular Biology, Immunology and Bioinformatics Laboratory, Department of Microbiology, Adeleke University, Ede, Nigeria.

¹³Genomics Unit, Helix Biogen Institute, Ogbomoso, Nigeria.

¹⁴Department of Microbiology, Federal University of Health Sciences, Ila-Orangun, Nigeria.

¹⁵Department of Biotechnology, Osun State University, Osogbo, Nigeria.

PubMed DOI

Abstract

The global proliferation of carbapenem-resistant Enterobacterales (CRE) constitutes one of the most urgent public health threats, yet high-resolution genomic data from sub-Saharan Africa remain critically scarce. We applied whole-genome sequencing (WGS) and comparative phylogenomics to characterise antimicrobial resistance determinants, virulence genes, and mobile genetic elements (MGEs) in three…

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