Reply to 'The method matters: free water imaging in Parkinson's disease is not a binary verdict'.

Yun Hwa Roh^1,2, Jinyoung Youn^3,4, Sang-Young Kim⁵, Hwan Heo⁶, Soohwa Song⁶, Beomseok Sohn⁷

¹Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

²Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

³Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

⁴Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.

⁵MR Clinical Science, Philips Healthcare, Seoul, Republic of Korea.

⁶Heuron Co., Ltd., Seoul, Republic of Korea.

⁷Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. beomseoksohn@gmail.com.

PubMed DOI

Abstract

We reply to the Matters Arising on our study comparing neuromelanin and free water imaging for early Parkinson's disease diagnosis. The authors raised considerations regarding image registration, age imbalance, repetition time, and conceptual framing. We clarify that our registration pipeline is validated for subcortical structures, that age does not account for neuromelanin's superior performance…

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