Health AI Central
Peer-Reviewed Publication
Oral Oncol2026;182108140.September 13, 2026Journal Article

Validation of the ninth edition pathological and clinical TNM classifications for salivary gland carcinoma.

Sami Alsulami1, Alexander Rühle2, Eugene Yu3, Jie Su4, Brian O'Sullivan5, Ali Hosni6, John N Waldron7, Ilan Weinreb8, Stephen Smith9, John de Almeida10, David Goldstein11, Christopher Mkl Yao12, Andrew McPartlin13, Andrew Bayley14, Scott V Bratman15, Ezra Hahn16, Andrew Hope17, John Kim18, Nauman Malik19, Enrique Sanz-Garcia20, Anna Spreafico21, Li Tong22, Wei Xu23, Eric Bartlett24, Shao Hui Huang25
1Division of Head and Neck Imaging, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: AlsulamiS10@mngha.med.sa.
2Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: alexander.ruehle@medizin.uni-leipzig.de.
3Division of Head and Neck Imaging, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Eugene.Yu@uhn.ca.
4Department of Biostatistics, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Susie.Su@uhn.ca.
5Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada; Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Brian.Osullivan@uhn.ca.
6Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Ali.Hosni@uhn.ca.
7Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada; Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: John.Waldron@uhn.ca.
8Department of Pathology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Ilan.Weinreb@uhn.ca.
9Department of Pathology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Stephen.Smith@uhn.ca.
10Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: John.deAlmeida@uhn.ca.
11Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: David.Goldstein@uhn.ca.
12Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: christophermkl.yao@uhn.ca.
13Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Andrew.McPartlin@uhn.ca.
14Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Andrew.Bayley@uhn.ca.
15Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Scott.Bratman@uhn.ca.
16Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Ezra.Hahn@uhn.ca.
17Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Andrew.Hope@uhn.ca.
18Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: John.Kim@uhn.ca.
19Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Nauman.Malik@uhn.ca.
20Division of Medical Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Enrique.SanzGarcia@uhn.ca.
21Division of Medical Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Anna.Spreafico@uhn.ca.
22Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Li.Tong@uhn.ca.
23Department of Biostatistics, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Wei.Xu@uhn.ca.
24Division of Head and Neck Imaging, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Eric.Bartlett@uhn.ca.
25Department of Radiation Oncology, the Princess Margaret Cancer Centre/University of Toronto, Canada; Department of Otolaryngology-Head and Neck Surgery, the Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address: Shaohui.Huang@uhn.ca.
PubMed DOI

Abstract

OBJECTIVES: To validate the performance of pathological and clinical UICC 9th edition/AJCC Version 9 (TNM9) classifications in salivary gland carcinoma (SGC). METHODS: Patients with newly diagnosed major or minor SGC treated between 2006 and 2021 were retrospectively reviewed. Cases were restaged using pathological and clinical TNM8 and TNM9 criteria to compare 5-year disease-free survival (DFS)…

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