Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension.

Yoshihito Morimoto^1,2, Yoshiaki Sato³, Katsuhiro Kato⁴, Hidenori Yamamoto¹, Kentaro Suzuki¹, Kiyotaka Go¹, Yoshie Fukasawa¹, Naoki Ohashi¹, Yoshiyuki Takahashi¹, Taichi Kato¹

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

²Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

³Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Aichi, Japan.

⁴Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

PubMed PMC DOI PDF

Abstract

RATIONALE: Although plexiform lesion (PL) formation in severe pulmonary arterial hypertension (PAH) is a therapeutic target, the mechanisms underlying their formation have not been fully elucidated. OBJECTIVE: To identify candidate proteins involved in PL formation by examining differentially expressed proteins (DEPs) in PAH lesions. METHODS: Proteomic remodeling was assessed before and after th…

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