Variations of Blood Concentration Levels of Reactive Carbonyl Species Among Three Case-Control Studies of Breast and Colorectal Cancer.

Susumu Tomono^1,2, Daichi Narushima³, Motoki Iwasaki^4,5, Taiki Yamaji⁴, Yoshio Kasuga⁶, Shoichiro Tsugane⁵, Noriyuki Miyoshi¹, Mamoru Kato³, Yukari Totsuka⁷, Michihiro Mutoh⁷, Hitoshi Nakagama⁸, Toshio Imai⁹

¹Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.

²Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan.

³Division of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan.

⁴Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.

⁵Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.

⁶Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan.

⁷Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tokyo, Japan.

⁸National Cancer Center, Tokyo, Japan.

⁹Central Animal Division, National Cancer Center Research Institute, Tokyo, Japan.

PubMed DOI

Abstract

Oxidative stress is one of the major causes of cancer. Interactions with proteins and nucleic acids of lipid peroxidation-derived reactive carbonyl species (RCS), which act as secondary signaling intermediates and contribute to oxidative stress signals, are associated with cancer development. The aim of the present study was to identify novel biomarkers for the detection of a high-risk group and/o…

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