Health AI Central
Peer-Reviewed Publication
Glia2026;74(11):e70222.November 1, 2026Journal Article

AKAP12 Regulates Perivascular OPC Accumulation in the Corpus Callosum During Cerebral Hypoperfusion.

Shintaro Kimura1,2, Munehiro Demura1, Hajime Takase1, Akane Mizutani1,3, Selin Dogan1, Shivani Jajoo1, Ji Hyun Park1, Josephine Lok1, Byung Gon Kim4, Akihiro Shindo3, Irwin H Gelman5, Ken Arai1
1Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
2Life Science Research Center, Gifu University, Gifu, Japan.
3Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
4Departments of Brain Science and Neurology, Ajou University School of Medicine, Suwon, South Korea.
5Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
PubMed DOI

Abstract

Oligodendrocyte precursor cells (OPCs) have been reported to interact with cerebral microvessels, but the extent and spatiotemporal regulation of this relationship across maturation and hypoperfusion-induced stress remain incompletely defined. Here, we quantified OPC-vessel relationships in the mouse corpus callosum using PDGFR-α/OLIG2/CD31 immunohistochemistry and distance-based spatial analysis,…

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