Health AI Central
Peer-Reviewed Publication
J Extracell Biol2026;5(9):e70188.September 1, 2026Journal Article

When EV Dose Is Not What It Seems: Quantitative Mismatch Between Particle Number- and Protein-Based Dosing.

Tímea Böröczky1,2,3, Mária Harmati1, Edina Gyukity-Sebestyén1, Tamás F Polgár4,5, Csenge Feinek2, Emma Balog1, Antal Martinecz6, Krisztina Buzás1,2, Gabriella Dobra1,2, Mátyás Bukva1,2
1Institute of Biochemistry Biological Research Centre HUN-REN Szeged Hungary.
2Department of Immunology University of Szeged Szeged Hungary.
3Doctoral School of Experimental and Preventive Medicine University of Szeged Szeged Hungary.
4Transmission Electron Microscope Laboratory, Core Facility HUN-REN Biological Research Centre Szeged Hungary.
5HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network University of Szeged Szeged Hungary.
6Certara Radnor Pennsylvania USA.
PubMed PMC DOI PDF

Abstract

Extracellular vesicles (EVs) are widely studied as mediators of intercellular communication, yet their quantitative characterization remains inconsistent. In this study, we investigated how vesicle release rate, cellular proliferation, and tumour origin jointly shape EV-associated protein output. Using a panel of 19 human, murine, canine and primate cancer- and non-cancer cell lines cultured under…

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