Health AI Central
Peer-Reviewed Publication
Transl Res2026September 16, 2026Journal Article

The AR/ARD1/DLGAP5 Axis Drives Oncogenesis and Immune Evasion via PD-L1 Upregulation in Androgen Receptor-Positive Triple-Negative Breast Cancer.

Chongwu He1, Bin Zhou2, Jing Chen3, Ruibo Tian4, Xiaoqiang Zeng5, Xianghua Wan6, Tenghua Yu7, Jun Zou8
1Department of Breast Surgery, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang 330029, Jiangxi, China.
2Department of Pathology, Jiangxi Dian Hua Xing Medical Laboratory Co., Ltd, Nanchang 330029, Jiangxi, China.
3Department of Nursing, Nanchang Medical College, Nanchang 330052, Jiangxi, China.
4Department of Thyroid and Breast Surgery, Xing'an League People's Hospital, Xing'an League, Ulanhot 137400, China.
5Jiangxi Medical College, Nanchang University, Nanchang 330031, Jiangxi, China.
6Department of Breast Surgery, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang 330029, Jiangxi, China. Electronic address: wanxh1996@163.com.
7Department of Breast Surgery, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, JXHC Key Laboratory of Tumor Microenvironment and Immunoregulation, Nanchang 330029, Jiangxi, China. Electronic address: yuthua2016@163.com.
8Department of Abdominal Oncology Surgery, Jiangxi Cancer Hospital, Nanchang 330029, Jiangxi, China. Electronic address: zoujun201507@126.com.
PubMed DOI

Abstract

Triple-negative breast cancer (TNBC) poses a significant clinical challenge due to its aggressive nature and lack of targeted therapies. A subset expressing the Androgen Receptor (AR) offers a therapeutic opportunity, yet the mechanisms remain incompletely understood. Breast cells were cultured under hormone-deprived or androgen-stimulated conditions with or without AR inhibitors. Short hairpin RN…

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