Early-Onset Colorectal Cancer: Clinical and Molecular Features with Emerging Insights from Comprehensive Genomic Profiling.

Amanda Nogueira¹, Jennifer Brondon¹, Konstantin Haradinov¹, Srinivasan Gopalakrishnan², Krane Huang¹, Debasri Mukherjee¹, Smita Agarwal³, Kyle C Strickland^4,5, Laura Vidal¹, Chinmayee Joshi¹, Rebecca Brookes², Rajeev Prasad⁶, Soma Das¹, Arun K Mankan¹, Archana Munje¹, Begona de Las Heras¹, Brajendra Prasad Singh⁷, Daniel Gandia¹, Shakti Ramkissoon^4,8, Fahmi Sabr Raza⁹, Isagani Chico¹, Sharadchandra K Prasad⁹, Judith Perez¹⁰, Anumeha Prasad¹¹, Debashis Sarker¹², Julien Taieb¹³, Kamal S Saini^14,15

¹Fortrea Inc., Durham, NC, USA.

²East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK.

³ConcertAI, Bangalore, India.

⁴Labcorp Oncology, Durham, NC, USA.

⁵Department of Pathology, Duke University Medical Centre, Durham, NC, USA.

⁶Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

⁷Max Smart Super Specialty Hospital, Saket, New Delhi, India.

⁸Department of Pathology, Wake Forest Comprehensive Cancer Centre, Wake Forest School of Medicine, Winston-Salem, NC, USA.

⁹Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK.

¹⁰The Larvol Group, San Francisco, USA.

¹¹Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK.

¹²Guy's and St Thomas' NHS Foundation Trust, London, UK.

¹³Université Paris Cité, SIRIC CARPEM, Georges Pompidou European Hospital, Paris, France.

¹⁴Fortrea Inc., Durham, NC, USA. Kamal.saini@nhs.net.

¹⁵Department of Medical Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. Kamal.saini@nhs.net.

PubMed DOI

Abstract

Early‑onset colorectal cancer (EOCRC), defined as colorectal cancer (CRC) diagnosed before 50 years of age, is increasing globally. Colorectal cancer is currently the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide, with GLOBOCAN 2024 estimating approximately 2.04 million new cases and 917,895 deaths in 2024. Recent studies indicate a sustained r…

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