Health AI Central
Peer-Reviewed Publication
Am J Med2026September 17, 2026Journal Article

Lipid deposition as a common feature of pneumonias of different etiologies.

Daria M Potashnikova1, Anna V Tvorogova2, Tatiana N Sotnikova3, Alexey A Komissarov4, Kirill N Zhuravlev3, Aleena A Saidova2, Valerya O Makarova3, Eugene A Arifulin5, Tatiana V Lipina6, Olesya M Shirokova7, Eugene S Melnikov3, Tatiana A Rodina3, Anna A Valyaeva8, Anastasia A Zharikova9, George O Zayratyants10, Oleg V Zayratyants11, Oleg V Kokorev12, Anna Tkachev13, Elena A Stekolshchikova13, Philipp E Khaitovich13, Eugene V Sheval14, Leonid B Margolis15, Elena J Vasilieva4
1City Clinical Hospital Named After I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia; Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia; Russian University of Medicine, Moscow, Russia.
2City Clinical Hospital Named After I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia; Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia.
3City Clinical Hospital Named After I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia.
4City Clinical Hospital Named After I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia; Russian University of Medicine, Moscow, Russia.
5Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
6Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia.
7Central Scientific Research Laboratory, Institute of Fundamental Medicine, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
8Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; Department of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
9Department of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
10Russian University of Medicine, Moscow, Russia; City Clinical Hospital Named After S.S. Yudin, Moscow Department of Healthcare, Moscow, Russia.
11Russian University of Medicine, Moscow, Russia; Avtsyn Research Institute of Human Morphology of Federal state budgetary scientific institution Petrovsky National Research Centre of Surgery, Moscow, Russia.
12GE HealthCare Russia, Moscow, Russia.
13Neuro Center RU, Moscow, Russia.
14Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
15Faculty of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia. Electronic address: leonidborisovichmargolis@gmail.com.
PubMed DOI

Abstract

BACKGROUND: Pneumonia is highly prevalent, yet lipid metabolism in the human pneumonic lung remains poorly characterized despite its essential role in pulmonary homeostasis and disease. Here, we report a systematic histological and molecular analysis of lipid deposition in pneumonias of different etiologies. METHODS: We analyzed fatal COVID-19 and non-COVID-19 pneumonias. Patients underwent ante…

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