Health AI Central
Peer-Reviewed Publication
Parasitol Int2026;103383.September 5, 2026Journal Article

Poly(hydroxybutyrate) nanoparticle-encapsulated albendazole enhances in vivo efficacy against the Echinococcus multilocularis germinal layer.

Patricia E Pensel1, Pablo R Cortez Tornello2, Clara M Albani3, Florencia Gatti3, Ingrid Redersdorff4, Karina Herrera Seitz4, Adriana Albanese3, Gustavo A Abraham2, C Elissondo María5
1Grupo Farmacoterapia Experimental, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM, CONICET-UNMdP), Facultad de Ciencias Exactas y Naturales - UNMdP, Centro Científico Tecnológico Mar del Plata - CONICET, Centro de Asociación Simple CIC PBA, Mar del Plata 7600, Argentina. Electronic address: patriciapensel@gmail.com.
2Instituto de Investigaciones en Ciencia y Tecnología de Materiales (UNMdP - CONICET), Mar del Plata 7600, Argentina.
3Grupo Farmacoterapia Experimental, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM, CONICET-UNMdP), Facultad de Ciencias Exactas y Naturales - UNMdP, Centro Científico Tecnológico Mar del Plata - CONICET, Centro de Asociación Simple CIC PBA, Mar del Plata 7600, Argentina.
4Instituto de Investigaciones Biológicas (UNMdP-CONICET), Mar del Plata 7600, Argentina.
5Grupo Farmacoterapia Experimental, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM, CONICET-UNMdP), Facultad de Ciencias Exactas y Naturales - UNMdP, Centro Científico Tecnológico Mar del Plata - CONICET, Centro de Asociación Simple CIC PBA, Mar del Plata 7600, Argentina. Electronic address: c.elissondo@gmail.com.
PubMed DOI

Abstract

Alveolar echinococcosis (AE), caused by the larval stage of Echinococcus multilocularis, is a severe zoonosis requiring prolonged anthelmintic therapy. Albendazole (ABZ) remains the treatment of choice; however, its poor aqueous solubility and low systemic bioavailability limit therapeutic efficacy and necessitate prolonged high-dose regimens. Improving the delivery of existing antiparasitic drugs…

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