Transcriptomic signatures of mind-body transformations therapy in breast cancer: Downregulation of the interferon signaling pathway.

Stefania Cocco¹, Mauro Cozzolino², Michela Piezzo³, Giovanna Celia⁴, Daniela Barberio⁵, Valentina Abate⁵, Alessandra Calabrese³, Claudia Von Arx³, Rossana Di Rienzo³, Susan Costantini⁶, Alfredo Budillon⁷, Michelino De Laurentiis⁸

¹Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy. Electronic address: s.cocco@istitutotumori.na.it.

²Department of Human, Philosophical and Educational Sciences, University of Salerno, Salerno, Italy.

³Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.

⁴Department of Theoretical and Applied Sciences, Ecampus University, Novedrate, Italy.

⁵Departmental Simple Unit of Psycho-oncology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.

⁶Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.

⁷Scientific Directorate, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.

⁸Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy. Electronic address: m.delaurentiis@istitutotumori.na.it.

PubMed DOI

Abstract

BACKGROUND: Growing evidence has shown that Mind-Body Transformations-Therapies (MBT-T) are able to modulate chronic inflammation, a well-known driver of cancer progression and drug resistance. In our previous work, we showed that a specific MBT-T protocol was able to reduce the release of various pro-inflammatory cytokines and chemokines in the sera of patients with breast cancer that completed a…

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